2. Signaling Pathways
  3. Anti-infection
  4. Parasite

Parasite

Parasite

Related Products

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Antiparasitics are a class of medications which are indicated for the treatment of parasitic diseases such as nematodes, cestodes, trematodes, and infectious protozoa.

Parasite Isoform Specific Products:

Parasite Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-110137A
    Furamidine
    		Inhibitor
    Furamidine (DB75) is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with an IC50 of 9.4 μM. Furamidine is selective for PRMT1 over PRMT5, PRMT6, and PRMT4 (CARM1) (IC50s of 166 µM, 283 µM, and >400 µM, respectively). Furamidine is a potent, reversible and competitive tyrosyl-DNA phosphodiesterase 1 (TDP-1) inhibitor. Inhibition of TDP-1 by Furamidine is effective both with single- and double-stranded DNA substrates but is slightly stronger with the duplex DNA. Furamidine is also an antiparasite agent.
    Furamidine
  • HY-151470
    Chitinase-IN-5
    		Inhibitor
    Chitinase-IN-5 (8i) is a potent chitinase OfChi-h inhibitor with an IC50 value of 0.051 μM. Chitinase-IN-5 shows good insecticidal activity, it can be used for the research of green pest control and management.
    Chitinase-IN-5
  • HY-172131
    Emoquine-1
    		Inhibitor
    Emoquine-1 is an orally active and potent antimalarial drug. Emoquine-1 is efficient against multidrug-resistant Plasmodium parasites, including the Artemisinin-resistant quiescent stage. Emoquine-1 is active against proliferative P. falciparum with IC50 values of 20-55 nM. Emoquine-1 is a candidate to fight Plasmodium parasites resistant to artemisinin-based combination therapies (ACTs) with a capacity to eliminate persistent parasites.
    Emoquine-1
  • HY-136450S
    Triclabendazole sulfoxide-d3
    		Inhibitor
    Triclabendazole sulfoxide-d3 is the deuterium labeled Triclabendazole sulfoxide. Triclabendazole sulfoxide (TCBZ-SO) is an orally active ABCG2 inhibitor with antiparasitic activity. Triclabendazole sulfoxide inhibits ABCG2-mediated active efflux and ATPase activity. Triclabendazole sulfoxide increases the intracellular accumulation of Mitoxantrone (HY-13502). Triclabendazole sulfoxide reduces the apical-directed transepithelial transport of Nitrofurantoin and Danofloxacin, while increasing their basolateral-directed transepithelial transport. Triclabendazole sulfoxide elevates the plasma levels of sulfasalazine in wild-type mice. Triclabendazole sulfoxide decreases ABCG2-mediated secretion of Nitrofurantoin into milk in wild-type lactating mice. Triclabendazole sulfoxide can be used in the research of insecticidal agents and cancers such as breast cancer.
    Triclabendazole sulfoxide-d<sub>3</sub>
  • HY-151484
    Anti-infective agent 4
    		Inhibitor
    Anti-infective agent 4 (compound 73) is an orally active inhibitor of Trypanosoma cruzi with an IC50 value of 0.016 μM. Anti-infective agent 4 effectively reduces parasite burden in vivo. Anti-infective agent 4 can be used for the research of infection.
    Anti-infective agent 4
  • HY-156063
    (2R,4R)-UCB7362
    		Inhibitor
    (2R,4R)-UCB7362 is the (2R,4R) isomer of UCB7362 (HY-151568). UCB7362 is an inhibitor of plasma proteinase X (PMX) with antimalarial activity.
    (2R,4R)-UCB7362
  • HY-163070
    Antimalarial agent 35
    		Inhibitor
    Antimalarial agent 35 (compound QP11) is a selective inhibitor FP2. Antimalarial agent 35 has antimalarial activity and shows synergistic effects when combined with chloroquine(HY-17589A).
    Antimalarial agent 35
  • HY-135811S1
    Desethyl chloroquine-d5
    		Inhibitor
    Desethyl chloroquine-d5 is deuterium labeled Desethyl chloroquine. Desethyl chloroquine is a major desethyl metabolite of Chloroquine. Chloroquine diphosphate is an inhibitor of autophagy and toll-like receptors (TLRs). Desethyl chloroquine possesses antiplasmodic activity.
    Desethyl chloroquine-d<sub>5</sub>
  • HY-B0887S1
    Permethrin-d9
    		Inhibitor 98.20%
    Permethrin-d9 is the deuterium labeled Permethrin. Permethrin (NRDC-143) is an insecticide, acaricide, and insect repellent; functions as a neurotoxin, affecting neuron membranes by prolonging sodium channel activation.
    Permethrin-d<sub>9</sub>
  • HY-161488
    Eugenol/BSA
    		Inhibitor
    Eugenol/BSA is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
    Eugenol/BSA
  • HY-N1480S2
    (-)-Fucose-13C-2
    (-)-Fucose-13C-2 is the 13C labeled (-)-Fucose. (-)-Fucose is classified as a member of the hexoses, plays a role in A and B blood group antigen substructure determination, selectin-mediated leukocyte-endothelial adhesion, and host-microbe interacti[
    (-)-Fucose-<sup>13</sup>C-2
  • HY-N1075
    Walsuronoid B
    		Inhibitor
    Walsuronoid B is a limonoid can be isolated from Walsura robusta and has weak antimalarial activity.
    Walsuronoid B
  • HY-162696
    mCMQ069
    		Inhibitor
    mCMQ069 is an orally active and potent antimalarial. mCMQ069 has potential for a single-dose cure and/or 28-day chemoprevention.
    mCMQ069
  • HY-W777922
    Nifursol-15N2,d2
    Nifursol-15N2,d2 is the deuterium and 15N-labeled Nifursol (HY-B1703). Nifursol is an orally active veterinary antibiotic. Nifursol inhibits Histomonas meleagridis. Nifursol prevents histomoniasis in turkeys. Nifursol is widely used in studies of Escherichia coli gastroenteritis in Salmonella-infected poultry and aquatic animals.
    Nifursol-<sup>15</sup>N<sub>2</sub>,d<sub>2</sub>
  • HY-168570
    Insecticidal agent 16
    		Inhibitor
    Insecticidal agent 16 (compound A21) is a potent insecticidal agent. Insecticidal agent 16 shows insecticidal activities against Plutella xylostella and Spodoptera frugiperda with LC50 values of 1.2 and 13.2 µg/mL, respectively.
    Insecticidal agent 16
  • HY-138502
    Melarsomine
    		Inhibitor
    Melarsomine is a trivalent arsenical compound used as an adulticide. Melarsomine can be used for the reserach of canine heartworm disease and other helminth infections.
    Melarsomine
  • HY-B1751S
    Quinidine-d3
    		Inhibitor
    Quinidine-d3 is the deuterium labeled Quinidine. Quinidine is an antiarrhythmic agent for the treatment of abnormal heart rhythms and also malaria.
    Quinidine-d<sub>3</sub>
  • HY-174343
    ELQ-121
    		Inhibitor
    ELQ-121 is a potent inhibitor of the ubiquinol-oxidation (QO)-site of parasites. ELQ-121 has IC50 of 0.05 nM against chloroquine sensitive and multidrug resistant P. falciparum in vitro. ELQ-121 inhibits T. gondii and N. caninum with IC50 below 1 nM in vitro. ELQ-121 suppresses B. besnoiti tachyzoite proliferation with an IC50 of 0.49 nM and induces mitochondrial disruption. ELQ-121 can form polyethylene glycol carbonate ester prodrug which demonstrates in vivo efficacy against P. yoelii in mice. ELQ-121 is suitable for antimalarial research.
    ELQ-121
  • HY-B0803S
    Lumefantrine-d18
    		Inhibitor
    Lumefantrine-d18 is the deuterium labeled Lumefantrine, which is an antimalarial agent.
    Lumefantrine-d<sub>18</sub>
  • HY-W014394R
    Vanillyl butyl ether (Standard)
    Protoporphyrin IX (Standard) is the analytical standard of Protoporphyrin IX. This product is intended for research and analytical applications. Protoporphyrin IX is a final intermediate in the heme biosynthetic pathway, which acts as a radiation sensitizer enhancing ROS generation even in a hypoxic state and inducing DNA damage. Protoporphyrin IX also acts as a photo sensitizer undergoing photobleaching that occurs through direct degradation by light irradiation. Protoporphyrin IX is formed and accumulated following 5-aminolevulinic acid (5-ALA) (HY-W000450) administration in the tumor cells of rats. Protoporphyrin IX causes selective improvement of basal cell carcinoma when activated red fluorescence of a peak wavelength at 405 nm. Protoporphyrin IX is promising for research of sonodynamic and photodynamic agents for a wide range of cancers, such as bladder cancer and nodular basal cell carcinoma.
    Vanillyl butyl ether (Standard)
Parasite Isoform Comparison

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